Canvassing for Opinion - aka "Blairs Brain on Cannabis"

IMHO prohibition sentiment requires inherent addiction to status quo, an incapacity to visualise beyond the here and now and a desperate desire to know others might feel the same... Reform is not revolutionary, rather it is evolutionary. Having survived banging your head against a brick wall the evolutionist relishes having stopped. / Blair

Saturday, August 26, 2006

Endocannabinoid Regulation of the Hypothalamo-Pitiutary-Adrenal Axis

Beat Lutz
Institute of Physiological Chemistry and Pathobiochemistry,
Johannes Gutenberg-University Mainz, GERMANY

The endocannabinoid system has recently emerged as an important modulator in a plethora of behavioural responses to both internal and external stressors under physiological and pathophysiological conditions.
In particular, the notion has been put forward that the endocannabinoid system is an endogenous system in order to stabilize and to maintain the body's homeostasis after stressors may have induced an imbalance.
Endocannabinoids and cannabinoid receptor type 1 (CB1 receptors) are present at most if not all levels of the hypothalamic-pituitary-adrenal (HPA) axis, and there is good evidence that CB1 receptor activation is able to modulate ACTH and corticosterone secretion. At the cellular level, endocannabinoids are able to regulate synaptic transmission by a mechanism called depolarization induced suppression of excitation (DSE) and of inhibition (DSI). Endocannabinoids are also able to regulate intracellular signaling cascades that subsequently may regulate the secretion of stress hormones. These features, together with behavioural assays and (neuro)endocrine investigations on mouse model systems lacking CB1 receptors and on rodents treated with CB1 receptor antagonist provide interesting new insights into the role of the endocannabinoid system on the regulation of the HPA axis and, consequently, also on stress and anxiety . Therefore, the endocannabinoid system may constitute a promising new therapeutic target in various disorders with imbalances in the HPA axis.
Still politicians pretend there is no medical foundation to self administration of THC, and continue to lock people up.
Criminalised cannabis is a health intervention with double jeopardy. (the minister of justice acts on the warrant of the minister of health)

The biopsychosocial consequences are self evident. Classified cannabis IS the imediment to achieving best practice public health.

Placing it in Class D is the expeditious remedy.
The right to possess herbals would be a barren right without the right to the business models that included cultivation or manufacture, transport, processing, quality control , storage and handling, sale and exchange. The crown even provides funding for health promotion messages.(it also collects GST on high 'value added' margin )

The above Lutz abstract is a complete validation of the harm reduction models proposed by Colorado University (Boulder) Biology Chair, Dr (Assoc Prof) Robert Melamede mentioned elsewhere in this blog. i.e. Harm reduction the cannabis paradox.

Also see The Endocannabinoid System: Friend or Foe?
February 15, 2006, Host: Dr. Kenneth Mackie
and 5th Forum of European NeuroScience, Vienna, July 2006

Advancing the Management of Cardiovascular and Metabolic Risk Factors: The Role of the Endocannabinoid System.

More recently NAEs have been shown to be part of the endocannabinoid signaling system. Recent investigation has shown that cannabinoid drugs (active ingredient D9-THC) act via membrane bound receptors (G-protein coupled) and NAEs act as endogenous ligands that react with the receptors CB1 and CB2. Anandamide (NAE20:4) binds to and activates CB1 receptors in neurons, initiating an intracellular signaling cascade that leads to changes in ion flux at the plasma membrane

Endocannabinoid Signaling in the brain: role of N-acylethanolamine metabolism

Blair Anderson
ph (643) 389 4065 cell 027 26572109
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