Canvassing for Opinion - aka "Blairs Brain on Cannabis"

IMHO prohibition sentiment requires inherent addiction to status quo, an incapacity to visualise beyond the here and now and a desperate desire to know others might feel the same... Reform is not revolutionary, rather it is evolutionary. Having survived banging your head against a brick wall the evolutionist relishes having stopped. / Blair

Thursday, March 10, 2011

An Abstract for the Elephant?

The elephant in the room with the 'grass ceiling'.

Earleywine Mitch,  Addiction (Abingdon, England) 2011;106(2):245-6; discussion 251-2
University at Albany, Psychology, SS 369, 1400 Washington Avenue, Albany, NY 12222, USA.
Any help with an Abstract for the Elephant in the Room?

Cannabinoid receptorImage via Wikipedia
I noted in the recent literature , "we have ascertained the presence and functionality in mouse embryonic stem cells (ESCs) of members of the endocannabinoid system that have been proposed as possible modulators of the survival and differentiation of various type of stem cells."

Characterization of the endocannabinoid system in mouse embryonic stem cells. Bari Monica; Tedesco Marianna; Battista Natalia; Pasquariello Nicoletta; Pucci Mariangela; Gasperi Valeria; Scaldaferri Maria Lucia; Farini Donatella; De Felici Massimo; Maccarrone Mauro, Stem cells and development 2011;20(1):139-47 Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.


The manifold actions of endocannabinoids on female and male reproductive events.

Epidemiological studies have highlighted the ever growing use of illegal drugs among teenagers. The negative effects of marijuana (a Cannabis sativa extract) on reproductive health are poorly known among young people, although chronic exposure to delta-9-tetrahydrocannabinol, the main psychoactive constituent of marijuana, impairs human reproductive potential by disrupting menstrual cycle, suppressing oogenesis and impairing embryo implantation and development, in women, and by increasing ejaculation problems, reducing sperm count and motility, and generating loss of libido and impotence, in men. Endocannabinoids, their metabolic enzymes and target receptors form the so called "endocannabinoid system" and they have been demonstrated to respond to fertility signals. In addition, they interfere with hormones, cytokines and other signalling molecules in both female and male reproductive events. In this review, we shall summarize the current knowledge on the endocannabinoid system, and on the multifaceted roles played by endocannabinoids in reproduction along the evolutionary axis from invertebrates to mammals. Furthermore, we shall discuss the potential use of distinct elements of the endocannabinoid system for the diagnosis and/or treatment of human infertility.

Bari Monica; Battista Natalia; Pirazzi Valentina; Maccarrone Mauro, Frontiers in bioscience : a journal and virtual library 2011;16():498-516 Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy

Whoooo.... bring on the vanilloids, much more interesting than pesky alcohol!

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