Canvassing for Opinion - aka "Blairs Brain on Cannabis"

IMHO prohibition sentiment requires inherent addiction to status quo, an incapacity to visualise beyond the here and now and a desperate desire to know others might feel the same... Reform is not revolutionary, rather it is evolutionary. Having survived banging your head against a brick wall the evolutionist relishes having stopped. / Blair

Sunday, February 02, 2014

Cannabis and psychosis: Neurobiology. A lesson in uncertainty?

Neuroscience Notebook
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Cannabis and psychosis: Neurobiology

 Full Text 
Indian Journal of Psychiatry,   Review Article


Shrivastava A, et al. – Cannabis is a known risk factor for schizophrenia, although the exact neurobiological process through which the effects on psychosis occur is not well–understood. In this review, the authors attempt to develop and discuss a possible pathway for the development of psychosis.

  • The authors examine the neurobiological changes due to cannabis to see if these changes are similar to those seen in schizophrenic patients the findings show similarities; however, these mere similarities cannot establish a 'cause-effect' relationship as a number of people with similar changes do not develop schizophrenia.
  • Therefore, the 'transition-to-psychosis' due to cannabis, despite being a strong risk factor, remains uncertain based upon neurobiological changes.
  • It appears that other multiple factors might be involved in these processes which are beyond neurobiological factors.
  • Major advances have been made in understanding the underpinning of marijuana dependence, and the role of the cannabinoid system, which is a major area for targeting medications to treat marijuana withdrawal and dependence, as well as other addictions is of now, it is clear that some of the similarities in the neurobiology of cannabis and schizophrenia may indicate a mechanism for the development of psychosis, but its trajectories are undetermined.





Shrivastava A, Johnston M, Terpstra K, Bureau Y. Cannabis and psychosis: Neurobiology. Indian J Psychiatry [serial online] 2014 [cited 2014 Feb 2];56:8-16. Available from: http://www.indianjpsychiatry.org/text.asp?2014/56/1/8/124708

Blair Anderson http://mildgreens.blogspot.com
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